IRVING H . ZUCKER and JOSEPH P . GILMORE
نویسندگان
چکیده
Experiments were performed to determine the influence of cardiac sympathetic efferent nerve stimulation on the discharge rate of atrial type B stretch receptors in the anesthetized, open-chest dog. In all experiments, the left stellate ganglion was stimulated following volume expansion. To determine the effects of stellate stimulation, the responses of atrial receptors were observed during the withdrawal of blood in steps following intravascular volume expansion. Stimulation of the stellate ganglion decreased receptor discharge and left atrial pressure in all experiments. A change from a control left atrial pressure of 2.5 cm H2O (in peak left atrial u-wave pressure) resulted in a mean increase in receptor discharge of 6.6 ±1 .4 spikes/cardiac cycle during stellate stimulation; however, a change from a control pressure of 0.0 cm H2O resulted in a mean decrease in receptor discharge of 1.5 ± 1.5 spikes/cardiac cycle. The curves relating the change in atrial receptor discharge to the change in left atrial pressure during hemorrhage and the curve for these parameters during stellate stimulation were not significantly different from each other. Apparently, the decreased discharge during sympathetic stimulation was the result of a decline in left atrial pressure rather than a result of any direct effect on the receptor per se.
منابع مشابه
IRVING H . ZUCKER and JOSEPH P . GILMORE Dog Evidence for an Indirect Sympathetic Control of Atrial Stretch Receptor Discharge
Experiments were performed to determine the influence of cardiac sympathetic efferent nerve stimulation on the discharge rate of atrial type B stretch receptors in the anesthetized, open-chest dog. In all experiments, the left stellate ganglion was stimulated following volume expansion. To determine the effects of stellate stimulation, the responses of atrial receptors were observed during the ...
متن کاملRenal effects of left atria1 distension in dogs
ZUCKER, IRVING H., LEONARD SHARE,AND JOSEPH P. GILMORE. Renal effects of left atrial distension in dogs with chronic congestive heart failure. Am. J. Physiol. 236(4): H554H560, 1979 or Am. J. Physiol.: Heart Circ. Physiol. 5(4): H554H560, 1979.-The renal response to left atrial balloon inflation in normal dogs was compared with that in dogs with chronic congestive heart failure (CHF). CHF was i...
متن کاملSpinal Cord GABA Receptors Modulate the Exercise Pressor Reflex in
Spinal Cord GABA Receptors Modulate the Exercise Pressor Reflex in 1 Decerebrate Rats 2 3 Han-Jun Wang, Wei Wang, Kaushik P. Patel, George J. Rozanski, Irving H. Zucker 4 5 Department of Cellular and Integrative Physiology 6 University of Nebraska Medical Center, NE 68198-5850, USA 7 8 Running Title: GABA receptors and Exercise Pressor Reflex 9 10 Address for correspondence: 11 Irving H. Zucker...
متن کاملGuidelines in cardiovascular research, a first for the American Journal of Physiology-Heart and Circulatory Physiology.
1 Guidelines in Cardiovascular Research; a First for the American Journal of 2 Physiology: Heart and Circulatory Physiology 3 4 Irving H. Zucker 5 University of Nebraska Medical Center 6 Omaha, NE 7 8 9 10 Running title: Guidelines papers 11 12 Correspondence: 13 Irving H. Zucker, Ph.D. 14 Department of Cellular and Integrative Physiology 15 University of Nebraska Medical Center 16 985850 Nebra...
متن کامل